26th June 2023

A 46-year-old man is admitted to hospital unwell with fevers, diarrhoea, and abdominal pain.

A 46-year-old man is admitted to hospital unwell with fevers, diarrhoea, and abdominal pain. He had a DCD renal transplant six months ago due to end-stage renal failure secondary to IgA nephropathy. The procedure was uncomplicated, he has had stable graft function and has been compliant with his medications.

Flexible sigmoidoscopy reveals multiple ulcers, and histology shows an ‘owl eye’ appearance of large cells with nuclear inclusion bodies.

Which virus could be responsible for this clinical picture?