26th June 2023

Definition of chronic tubulointerstitial nephritis (CTIN)

In chronic tubulointerstitial nephritis there is scarring of the tubulointerstitium, characterised by tubular atrophy (defined as reduction in tubular diameter of more than fifty percent), and interstitial fibrosis. It presents as slowly progressive renal impairment and is normally asymptomatic, however, proteinuria, polyuria or nocturia may be present.