10th July 2023

Paraneoplastic Cutaneous Manifestations

Dermatological signs can be seen in various types of malignancy, with some being more common in certain types of neoplasia.

Malignancy	Cutaneous manifestation
Gastrointestinal adenocarcinoma	Acanthosis nigricans Acanthosis palmaris
Bronchial carcinoma	Erythema gyratum repens (wood grain pattern) Acanthosis palmaris (tripe palms) Clubbing
Lymphoma	Acquired ichthyosis Erythroderma (also seen in leukaemia) Generalised pruritus
Glucagonoma	Necrolytic migratory erythema
Pancreatic carcinoma	Migratory thrombophlebitis
Myeloproliferative tumours	Pyoderma gangrenosum Sweet’s syndrome (febrile neutrophilic dermatoses) Herpes zoster
Oesophageal carcinoma	Tylosis
T cell lymphoma	Mycosis Fungoides

Table 3: Types of cutaneous manifestations in internal malignancies

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