1st August 2023

A 47-year-old man with HIV presents to A&E with a one week history of fever and headache.

A 47-year-old man with HIV presents to A&E with a one week history of fever and headache. That morning he appeared to have deteriorated, becoming drowsy, and vomited several times. His brother rang an ambulance. Further investigations are conducted following hospital admission, and a positive CSF culture with an Indian ink stain confirms the diagnosis.

What is the most likely diagnosis?

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