16th January 2024

Presentation

As this condition demonstrates multi-organ system involvement, people may present with a wide variety of clinical symptoms and signs. Normally, at least two organ systems are involved at the time of diagnosis, with 90% of patients with GPA experiencing symptoms and signs indicating involvement of the respiratory tract consistent with diagnoses such as LRTI or pneumonia. The table below summarises the different systems that can be involved with some of the associated signs and symptoms that may be present.

Table 1: Summary table of the most common organs/systems affected in GPA, with associated signs and symptoms that can be seen in GPA. Adapted from: Falk, R., Merkel, P. and King Jr, T. (2022) Granulomatosis with polyangiitis and microscopic polyangiitis: Clinical manifestations and diagnosis, UpToDate. Edited by R. Glassock et al. Available at: https://www.uptodate.com/contents/granulomatosis-with-polyangiitis-and-microscopic-polyangiitis-clinical-manifestations-and-diagnosis?search=gpa&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 (Accessed: January 15, 2023) and Molloy, E. (2022) BMJ Best Practice Granulomatosis with polyangiitis. Available at: https://bestpractice.bmj.com/topics/en-gb/327/pdf/327/Granulomatosis%20with%20polyangiitis.pdf (Accessed: January 15, 2023).