5th February 2024

A 56-year-old male is diagnosed with colorectal cancer. He was commenced on capecitabine and oxaliplatin

A 56-year-old male is diagnosed with colorectal cancer. He was commenced on capecitabine and oxaliplatin for his chemotherapy regime. He presents to the acute oncology service ten days following his first cycle of chemotherapy with erythematous hands. This began with the tingling and tightness of his fingers. Following this, it developed into erythematous changes on the palms and soles of his hand. He also notes the peeling of his skin with small patches of blisters forming.

This was his first cycle of these chemotherapy agents.

Which of the following is the mechanism of action of the likely culprit medication?

Select the SINGLE most appropriate option from the list below. Select ONE option only.