5th February 2024

A 45-year-old female with known rheumatoid arthritis attended the clinic for a routine follow-up

A 45-year-old female with known rheumatoid arthritis attended the clinic for a routine follow-up. She has been commenced on a DMARD for the past 18 months with a good response. However, she noted worsening shortness of breath and dry cough developing over the past six months. Her CXR showed mild bilateral reticular opacities. Infectious screens were negative with normal sputum culture and bronchoalveolar lavage.

Given the MOST LIKELY causative agent for breathlessness, which of the following best describes its mode of action?

Select the SINGLE most appropriate option from the list below. Select ONE option only.