14th February 2024

A 2-year-old male presents with recurrent chest infections, skin infections and abscesses

A 2-year-old male presents with recurrent chest infections, skin infections and abscesses. Microbiology results have revealed the causative organisms to be Staphylococcus aureus and Pseudomonas aeruginosa. Blood tests during this time revealed raised CRP levels but normal white cell count (WBC) and immunoglobulin levels. Nitroblue tetrazolium (NBT) reduction test showed an activity of zero when compared to normal adult control.

Given the likely diagnosis, which of the following dysfunctions contributed towards the pathogenesis of the condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.