16th February 2024

A 34-year-old female presents with chronic diarrhoea and weight loss

A 34-year-old female presents with chronic diarrhoea and weight loss for the past 12 months. Her diarrhoea is watery, foul-smelling and difficult to flush. She denied any previous travel. She reports recurrent sinusitis in the past. She was also hospitalised twice with severe pneumonia. Blood tests revealed low levels of tissue transglutaminase (tTG) antibodies. Historical blood tests revealed normal response to vaccinations. Stool microscopy and cultures were negative.

Which of the following diagnoses explains her diarrhoea?

Select the SINGLE most appropriate option from the list below. Select ONE option only.