18th February 2024

A 32-year-old female presents with generalised fatigue, malaise and weight loss

A 32-year-old female presents with generalised fatigue, malaise and weight loss. This was also associated with arthralgia in her wrists and knees. She also experienced lower limb oedema and frank blood in her urine. Examination revealed a malar rash across her cheeks and nose. Her BP was 160/100mmHg. Blood tests showed raised creatinine and urea. Urinalysis showed 4+ for blood and proteins.

Which of the following best describes the pathogenesis of the underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.