19th February 2024

A 34-year-old female with asthma presents to the respiratory clinic with worsening shortness of breath

A 34-year-old female with asthma presents to the respiratory clinic with worsening shortness of breath and wheeziness. Episodes of coughing up mucous plugs accompanied this. Her asthma control was stable up to this point.

Examination revealed widespread expiratory wheeze. HRCT revealed centrilobular nodules with mild upper lobar bronchiectasis. Blood tests showed an eosinophilia with raised serum IgE. She tested positive for IgE-specific antibodies against Aspergillus fumigatus.

Given the likely diagnosis, which hypersensitivity reaction is the underlying pathogenesis for this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.