19th February 2024

A 45-year-old male presents to the acute medical unit with a loss of coordination and balance

A 45-year-old male presents to the acute medical unit with a loss of coordination and balance. He has numbness and weakness in his upper and lower limbs. He also notes fatigue and shortness of breath despite minimal exertion. Examination reveals mild jaundice in his sclera. Romberg’s test was positive. He had bilateral loss of fine touch and proprioception with normal temperature and pain sensation in his extremities. He had hyperreflexia, upgoing plantars and absent ankle reflexes. Blood tests showed pancytopenia with an elevated MCV. Folate levels were normal.

Which autoantibodies are associated with a condition that can result in the clinical picture above?

Select the SINGLE most appropriate option from the list below. Select ONE option only.