19th February 2024

A 76-year-old female presents with unsteadiness and diplopia

A 76-year-old female presents with unsteadiness and diplopia. This was also associated with memory loss and tremors. Neurological examination reveals involuntary conjugate fast eye movements in all directions. This does not resolve when she is asked to focus on an object. She also had involuntary tremors in her jaw at rest. Involuntary twitching was noted along her face and tongue. Truncal ataxia was noted. CT chest has shown a 3cm irregular spiculate lung nodule in the right middle lobe.

Which autoantibodies are most likely to result in this clinical condition?

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