19th February 2024

A 45-year-old female presents to the rheumatology clinic with swollen fingers

A 45-year-old female presents to the rheumatology clinic with swollen fingers. It has limited her ability to grip and complete house tasks. Her fingers are exceptionally stiff in the morning but ease off throughout the day. She also reports increased shortness of breath over the past 4 months and can only mobilise short distances at present.

Examination shows multiple painful, swollen joints in her hands and feet at her MCP, MTP, and PIP joints. X-rays reveal juxta-articular erosions, osteopenia and loss of joint space. CXR reveals lower zone reticular changes.

Which of the following antibodies is most specific for diagnosing the underlying condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.