19th February 2024

A 40-year-old female presents to the acute medical unit with shortness of breath

A 40-year-old female presents to the acute medical unit with shortness of breath,  pleuritic chest pain and haemoptysis. D-dimer was raised, and a CTPA revealed a filling defect within the left pulmonary artery. Her medical history included three miscarriages at 6-9 weeks gestation, but no cause had been identified. She also had a previous unprovoked DVT 9 months before her admission, which was treated with apixaban. Examination revealed bilateral livido reticularis along her lower limb. She was hypertensive with 2+ protein in her urine. Blood tests showed thrombocytopenia.

Given the likely underlying diagnosis, which autoantibodies are associated with this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.