19th February 2024

A 56-year-old male has been having difficulty grasping onto objects and difficulty walking

A 56-year-old male has been having difficulty grasping onto objects and difficulty walking due to a foot drop. He reported feeling wheezy for the past three weeks and has been commenced on salbutamol and steroid inhalers without any improvement in symptoms. He is known to have recurrent issues with sinusitis and rhinitis. Previous reviews from ENT have shown multiple nasal polyps.

Nerve conduction studies show a mononeuritis multiplex. Spirometry shows an obstructive pattern. CXR have shown multiple bilateral patchy infiltrates. Bloods have shown raised eosinophil counts.

Which of the following autoantibodies is likely associated with the underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.