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22nd February 2024

A 40 year old male weighing 90kg presents to A&E in status epilepticus.

A 40 year old male weighing 90kg presents to A&E in status epilepticus. A loading dose of IV Phenytoin is prescribed followed by an IV infusion of 100mg. The Phenytoin for infusion is presented in 250mg/5ml ampoules and then diluted in 0.9% NaCl to a concentration of 10mg/1ml.

How much 0.9% NaCL would need to be added to 100mg Phenytoin 250mg/5ml solution to achieve a concentration of 10mg/1ml?

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