22nd February 2024

A 50 year old male weighing 80kg is started on a once daily regimen of IV Gentamicin 7mg/kg after presenting with symptoms suggestive of severe community-acquired pneumonia.

A 50 year old male weighing 80kg is started on a once daily regimen of IV Gentamicin 7mg/kg after presenting with symptoms suggestive of severe community-acquired pneumonia. He reports feeling short of breath and is currently requiring 5 litres of O2 via a venturi mask. He also has a productive cough. A blood sample to measure his plasma concentration of Gentamicin is taken 8 hours after his last dose of Gentamicin:

Gentamicin Plasma Concentration – 10 mg/L

(https://pharmaceutical-journal.com/article/ld/gentamicin-dose-regimens-and-monitoring)

Select the most appropriate option for managing this patient’s Gentamicin regimen