29th February 2024

A 28-year-old male from Greece presents to the genetic clinic with his wife

A 28-year-old male from Greece presents to the genetic clinic with his wife. He had been diagnosed with beta-thalassemia trait during childhood, which has been managed well with regular blood transfusions. He is keen to start a family, but genetic testing has shown that his wife is also a carrier for beta-thalassemia, and further tests reveal mild anaemia with no clinical impact.

What are the chances that his children will have a normal phenotype?

Select the SINGLE most appropriate option from the list below. Select ONE option only.