A 48-year-old man has presented to the GP with increased fatigue and malaise | Medibuddy
29th February 2024

A 48-year-old man has presented to the GP with increased fatigue and malaise

A 48-year-old man has presented to the GP with increased fatigue and malaise. He has experienced some joint pains along his hands bilaterally and has noted that he has developed erectile dysfunction over the past six weeks. He had presented himself to his GP as his friends had also noted that his skin appeared darker than usual and wondered if he had been abroad recently.

Blood tests were performed with the following results:

Blood test Value Normal range
Bilirubin 16 <21μmol/L
ALT 80U/L <41U/L
AST 95U/L 1-45U/L
ALP 250 U/L 30-130U/L
Ferritin 650ng/ml <300ng/ml
Transferrin saturation 65% 20-50%
HbA1c 85mmol/mol 20-47mmol/mol

He has two children with his wife, who is well. His wife informs you that her parents were well, but her brother was affected by a liver condition, needing repeated trips to the hospital for venesection for treatment.

What are the chances that the patient’s children will be affected by this condition?

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