4th March 2024

A 40-year-old man presents to the acute medical unit with jaundice. He was recently given nitrofurantoin

A 40-year-old man presents to the acute medical unit with jaundice. He was recently given nitrofurantoin to manage his UTI. He reported fatigue and malaise approximately 24 hours after commencing his antibiotics and noticed yellowing of his sclera 72 hours later. Abdominal examination was unremarkable.

Blood tests were taken with the following results:

The remainder of his LFTs were normal. A peripheral blood smear showed Heinz’s body. He reports that his Greek grandfather had a similar reaction after receiving co-trimoxazole while in the hospital for cholecystitis.

Given the likely diagnosis, what are the chances that his daughter will develop a similar condition assuming penetrance of 100% and his wife is well with no known medical conditions?

Select the SINGLE most appropriate option from the list below. Select ONE option only.