4th March 2024

A 29-year-old female is under yearly review by the endocrine clinic for her ongoing medical condition

A 29-year-old female is under yearly review by the endocrine clinic for her ongoing medical condition. Her condition presented at 15 days old with lethargy and reduced oral intake. Her mother had reported that she was well immediately following birth. Examination at that time revealed a raised respiratory rate with bradycardia and hypotension. She had dry mucous membranes and sunken fontanelles. Her blood at the time showed hyperkalaemia, hyponatremia and metabolic acidosis. On examination, she had clitoromegaly with labial fusion.

Which enzyme deficiency is most likely to result in the underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.