5th March 2024

A 21-year-old male is being seen in the genetics clinic for counselling. He is known to have had renal cancer

A 21-year-old male is being seen in the genetics clinic for counselling. He is known to have had renal cancer as a child, which was managed with a nephrectomy. Genetic analysis revealed a mutation within the WT1 gene. He is concerned that his child will develop a similar renal cancer.

What are the chances that his child develops a similar malignancy assuming a penetrance of 100% and his wife does not carry the gene mutation?

Select the SINGLE most appropriate option from the list below. Select ONE option only.