5th March 2024

A 24-year-old male presents to the haematology clinic with fever, night sweats, lymphadenopathy and abdominal pain

A 24-year-old male presents to the haematology clinic with fever, night sweats, lymphadenopathy and abdominal pain. Imaging confirms the presence of widespread lymphadenopathy along his abdomen. Blood tests show elevated LDH and uric acid levels. Histology reveals a “starry sky” appearance with B-cell monoclonal proliferation with basophilic cytoplasm, lipid vacuoles, multiple small nucleoli and stippled chromatin. Genetic analysis reveals a mutation in the c-Myc gene.

Which of the following genetic mutations is responsible for his underlying condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.