24th April 2024

A 63-year-old gentleman with an established history of angina attends for review.

A 63-year-old gentleman with an established history of angina attends for review. He has been compliant with prescribed medications which include bisoprolol, amlodipine, atorvastatin, and standard-release isosorbide mononitrate. He reports lately his medications have not been helping to control his symptoms as well as they used to. You suspect he has developed nitrate tolerance. What is the next best step with regards to his isosorbide mononitrate? 

Select the SINGLE most appropriate option from the list below. Select ONE option only.