29th April 2024

Management

Dopamine replacement using levodopa and a peripheral dopa-decarboxylase inhibitor is the most effective treatment for PD. Levodopa can, however, be associated with the development of dyskinesia, motor fluctuations and hallucinations.

Dopamine agonists can also be used but are associated with impulse control disorders. These, along with Monoamine oxidase-B inhibitors (MAO-B) and Catechol-O-methyltransferase (COMT) inhibitors can be used as an adjunct to levodopa in those who develop dyskinesia or motor fluctuations.