4th May 2024

A 45-year-old man with a known history of polycythemia vera (PV) presents for routine follow-up.

A 45-year-old man with a known history of polycythemia vera (PV) presents for routine follow-up. He has no history of thrombosis and has well-controlled hypertension. His current treatment includes phlebotomy and low-dose aspirin. Laboratory investigations show:

White cell count: 11.2 x 10⁹/L (4.0–11.0)

Haemoglobin: 182 g/L (135–175)

Platelets: 460 x 10⁹/L (150–400)

Haematocrit: 52%

Which is the most appropriate next step in the management of this patient?