5th May 2024

A 16-year-old female with cystic fibrosis presents with a 2-week history of increased cough and sputum production. She reports no fever or weight loss.

A 16-year-old female with cystic fibrosis presents with a 2-week history of increased cough and sputum production. She reports no fever or weight loss. Her usual treatment includes dornase alfa, hypertonic saline inhalation, and high-frequency chest wall oscillation therapy. She has been hospitalised twice in the past year for pulmonary exacerbations and her last sputum culture grew Pseudomonas aeruginosa.

What is the most appropriate next step in managing her current exacerbation?