5th May 2024

A 10-year-old boy with cystic fibrosis presents with a 1-week history of increased cough and a change in sputum colour from clear to green.

A 10-year-old boy with cystic fibrosis presents with a 1-week history of increased cough and a change in sputum colour from clear to green. He has a history of chronic Pseudomonas aeruginosa colonisation and is on regular inhaled tobramycin therapy. His last hospital admission was 3 months ago for a pulmonary exacerbation. On examination, he is afebrile, with a respiratory rate of 22 breaths per minute and oxygen saturation of 96% on room air. Lung auscultation reveals bilateral crackles.

Which of the following is the most appropriate management for his current condition?