20th June 2024

A 46-year-old gentleman is admitted to hospital with a 4 day history of high fever, malaise, and anorexia

A 46-year-old gentleman is admitted to hospital with a 4 day history of high fever, malaise, and anorexia. His temperature is 39.5 degrees Celsius, blood pressure is 104/62 mmHg, pulse rate is 118/min, respiratory rate is 22/min and SpO2 is 94% on room air. On examination, there is a new pan-systolic murmur over the left sternal edge. He has a history of IV drug use and multiple needle marks on his upper limbs. Blood tests and blood cultures are taken. An empirical diagnosis of infective endocarditis is made. He is awaiting an echocardiogram.

What is the appropriate initial antibiotic regime for this patient?

Select the SINGLE most appropriate option from the list below. Select ONE option only.