20th June 2024

A 66-year-old man is admitted to hospital with a 3 week history of fevers

A 66-year-old man is admitted to hospital with a 3 week history of fevers, malaise and anorexia. He is pyrexial, blood pressure is 124/62 mmHg, pulse rate is 108/min, respiratory rate is 20/min and SpO2 is 95% on room air. On examination, there is a new pan-systolic murmur over the left sternal edge. He has no past medical history of note and is not taking any medications. He is allergic to penicillin. Blood tests and blood cultures are taken. An empirical diagnosis of infective endocarditis is made. He is awaiting an echocardiogram.

What is the appropriate initial antibiotic regime for this patient?

Select the SINGLE most appropriate option from the list below. Select ONE option only.