21st June 2024

A 52-year-old African male is referred to the emergency department with rapid onset of a painful, swollen knee

A 52-year-old African male is referred to the emergency department with rapid onset of a painful, swollen knee. This occurs within two weeks of starting first-line anti-tuberculosis medication. Past medical history includes stage II chronic kidney disease and hypertension. The patient is afebrile on examination, with normal vital signs. Examination of the knee reveals a large effusion, with a reduced range of motion, marked erythema, warmth and tenderness of the knee joint. With respect to the patient’s prescribed medications, which of the following has most likely precipitated this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.