8th July 2024

A 55-year-old male presents with a few weeks history of lethargy & poor appetite

A 55-year-old male presents with a few weeks history of lethargy & poor appetite. He is known to have an HIV infection and is on antiretroviral therapy.

Investigations show: Hb 110 g/L (115-165), WBC 3.2×10⁹/L (4-11), Platelet 160×10⁹/L (150-400), Na 135 mmol/L (135-145), K 5.2 mmol/L (3.5-5), Urea 9.4mmol/L (2.5-7.5), Creatinine 160 μmol/L (60-110), CRP 28 mg/L (<5). Urine Dipstick shows 3+ protein and is negative for blood. US KUB shows normal sized kidneys with no hydronephrosis. Kidney function tests were normal on the last follow up 2 months ago. What is the most likely diagnosis in this case?

Select the SINGLE most appropriate option from the list below. Select ONE option only.