15th July 2024

A 23-year-old female with no past medical history who is 12 weeks pregnant presents with lower limb oedema

A 23-year-old female with no past medical history who is 12 weeks pregnant presents with lower limb oedema, a serum albumin of 17g/L and a urine protein creatinine ratio (uPCR) of 450 mg/mmol. Her ANA and dsDNA are negative. Her complements are normal. She has a positive p-ANCA pattern (+) with negative MPO and PR3 antibodies. Her blood pressure is 118/78. Her HbA1C is 38 and she is not a known diabetic. Her creatinine is stable at 52 µmol/l (no baseline available). What is the most likely diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.