30th August 2024

Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency

G6PD is an X-linked recessive disorder that clinically encompasses a spectrum of haemolytic syndromes. Patients can have a normal life span and be asymptomatic however they may have episodic anaemia or haemolytic crises. Fava beans, infections and medications can precipitate a crisis.

Drugs which may cause haemolysis include sulphonamides, sulfasalazine, sulfonylureas, ciprofloxacin and primaquine.

Reference

• Glader B. Genetics and pathophysiology of glucose-6-phosphate dehydrogenase (G6PD) deficiency. Means R, Raby B, editors. 2024