16th September 2024

Management

Transsphenoidal microadenomectomy is the first-line treatment choice, with radiotherapy being a second-line option for patients in whom surgery is contraindicated or was not successful. Medications are often used either prior to surgery or after to aid with suppression of cortisol suppression. Two agents licensed for this include metyrapone and ketoconazole. Post-operative vasopressin deficiency and SIADH can occur.