24th February 2025

A 60-year-old man with a BMI of 35 and long-standing, well-controlled asthma has been troubled by on-and-off bilateral knee pain, typically scoring 3/10, but during a walking holiday scored 5/10.

A 60-year-old man with a BMI of 35 and long-standing, well-controlled asthma has been troubled by on-and-off bilateral knee pain, typically scoring 3/10, but during a walking holiday scored 5/10. A diagnosis of OA is suspected based on his clinical examination and knee X-rays, which show bilateral severe joint space narrowing, osteophytes and subchondral sclerosis. He takes no regular medications, bar a salbutamol inhaler PRN and has no known drug allergies. Which of these management options is the least likely to be effective?

Select the SINGLE most appropriate option from the list below. Select ONE option only.