26th February 2025

Overview of Sjögren’s syndrome

Sjögren’s syndrome is an autoimmune disorder where the predominant pathophysiological feature is lymphocytic infiltration of exocrine glands. Clinical manifestations can vary from sicca symptoms to systemic involvement. Sjögrens can be primary, where it is an isolated phenomenon, or secondary, where it is associated with another autoimmune condition, such as rheumatoid arthritis, SLE or primary biliary cirrhosis.

It is most common in females, with onset in middle age, and has a similar prevalence to rheumatoid arthritis of 1%.