11th May 2025

A 42-year-old woman presents to general practice.

A 42-year-old woman presents to general practice. She has recently been diagnosed with pulmonary arterial hypertension and is under the care of a specialist centre. No secondary causes of pulmonary hypertension were identified. She describes her maternal grandfather dying at age 60 from a similar clinical presentation. Which of the following genetic mutations is most associated with familial pulmonary arterial hypertension?

Select the SINGLE most appropriate option from the list below. Select ONE option only.