11th May 2025

A 38-year-old woman presents to general practice.

A 38-year-old woman presents to general practice. She reports feeling more tired and breathless on exertion over the last few months, additionally she has found swallowing more difficult and has subsequently lost a stone in weight over the last 3 months. You notice the skin on hands is tight and she has multiple telangiectasia on her face and chest. On further questioning she confesses to a long history of aches in multiple joints. After arranging further investigations, a diagnosis of pulmonary hypertension is made. Given the likely underlying aetiology, which of the following autoantibodies are most likely to be present in this patient? 

Select the SINGLE most appropriate option from the list below. Select ONE option only.