16th May 2025

A 35-year-old woman undergoes a living-donor-kidney transplant.

A 35-year-old woman undergoes a living-donor-kidney transplant. Her last dialysis session was just before the transplant. Renal failure was due to hypertension and type 2 diabetes mellitus. The patient will receive a dose of thymoglobulin today and convert to oral mycophenolate mofetil and steroids. The patient seems to be doing exceptionally well, demonstrated by a strong appetite and a good report from physical therapy. The incision site is clean, and the nurse reports no complaints of pain. Laboratory test results are Na 135 mmol/L, K 4.1 mmol/L, Cl 100 mmol/L, urea 10.7 mmol/L, Cr 194 micromol/L (Before transplant 405 micromol/L),. Based on her physical examination and labs, the team decides she is stable enough to start oral tacrolimus IR.  What is the mechanism of action of tacrolimus?

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