19th May 2025

Prevention of nephrotoxicity

General steps to minimise the likelihood of nephrotoxicity include:

• Check baseline renal function & monitor as appropriate during therapy with potentially nephrotoxic medications 
• If appropriate, adjust dosages to account for renal function 
• Ensure patients are sufficiently hydrated and any depletion of circulating volume is restored with intravenous fluids as necessary
• Correct risk factors for nephrotoxicity where possible (e.g. treatment of sepsis, congestive cardiac failure)
• Avoid concomitant use of nephrotoxic drugs 
• Use non-nephrotoxic alternatives when possible.