19th May 2025

You are reviewing Mrs Grey, a 70-year-old patient in clinic.

You are reviewing Mrs Grey, a 70-year-old patient in clinic. She has been prescribed ramipril by her GP to treat her hypertension. Her blood tests today show a significant decline in her renal function since she was initiated on this drug. Which of the following mechanisms is most likely responsible for her impaired renal function?

Select the SINGLE most appropriate option from the list below. Select ONE option only.