7th August 2020

A 40-year-old woman has had an excision biopsy of a suspicious lesion on the dorsum of her hand

A 40-year-old woman has had an excision biopsy of a suspicious lesion on the dorsum of her hand. The histology report states there are nests of squamous epithelial cells from the epidermis and extend into the dermis. Malignant cells show a large nucleus with eosinophilic cytoplasm. There are also keratin pearls present. 

What is the most likely diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.