25th May 2025

VIPomas

VIPomas produce an excess of vasoactive intestinal peptide (VIP). These usually originate from non-B islet cells of the pancreas. VIPomas cause watery diarrhoea, hypokalaemia, achlorhydria (WDHA syndrome). Small tumours can be removed surgically, however this is often not an option as there is a high rate of liver metastasis at the time of diagnosis. This is often due to a lack of symptoms from the original tumour and patients may only become symptomatic with diarrhoea once liver metastases occu