27th May 2025

Epidemiology

Cushing’s syndrome is uncommon with an incidence of 40 per million. It more commonly affects females than males (3:1). Cushing’s disease (from pituitary secretion of ACTH) affects females to a greater degree (3:1 to 5:1), with a peak age of onset between 25 to 40 years of age. A greater prevalence of 2% to 5% is found in obese patients with type 2 diabetes mellitus.