4th June 2025

Management

Primary cutaneous follicle centre lymphoma:

• A single lesion or limited area of disease will be treated with radiotherapy or surgery.
• Numerous lesions may be treated with a range of therapies including topical agents, cryotherapy, radiation or systemic treatments.
• Disseminated or very large lesions may be treated with chemotherapy (e.g. R-CHOP).
• PCFCL may sometimes be observed without treatment, as lesions may remain stable in size or may even subside.

Primary cutaneous marginal zone B-cell lymphoma:

• As with PCFCL, a single lesion or limited area of disease may be treated with radiotherapy or surgery (note – relapse rates for radiotherapy are higher for PCMZBCL).
• Numerous lesions may be treated with a range of therapies including chemotherapy or rituximab.
• Disseminated or very large lesions may be treated with chemotherapy (e.g. R-CHOP).
• PCMZBCL in patients with Borrelia burgdorferi can be treated with antibiotics.

Primary cutaneous diffuse large B-cell lymphoma, leg-type:

• Limited or diffuse disease is treated with radiotherapy +/- R-CHOP.