10th August 2020

A 45-year-old woman presents to primary care with symptoms of depression, weight gain and tiredness

A 45-year-old woman presents to primary care with symptoms of depression, weight gain and tiredness. On examination, you note bradycardia, dry skin and bilateral periorbital oedema. Following appropriate investigations, you decide on a diagnosis of hypothyroidism. 

Deposition of which of the following substances is the cause of the skin changes seen in hypothyroidism?

Select the SINGLE most appropriate option from the list below. Select ONE option only.