5th June 2025

Epidemiology

Different world populations have different prevalence, with higher rates in the US compared to Europe or Asia. The prevalence is 88 per million seen in England compared to 250 per million adults in the US. Women are more often affected, with a ratio of 5:1 female to male. SSc is rare in childhood, more common in young adults and has a peak incidence in patients’ 50s.