7th June 2025

A 25-year-old female of African Caribbean origin presents with an itchy rash on the shins of her legs bilaterally.

A 25-year-old female of African Caribbean origin presents with an itchy rash on the shins of her legs bilaterally. The lesions are also present on the dorsum of her foot. On further examination, similar but less severe lesions were present on her elbows. She mentions that this rash was present since she was a child and that her mother also has a very similar rash. She had no recent fevers or illnesses. 

A mutation in which of the following genes is most likely responsible for the manifested disease?

Select the SINGLE most appropriate option from the list below. Select ONE option only.